Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 58 mcg/L [1]
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 6-8 h [1]
  Bioavailability: The bioavailability of drug is 25% [1]
  Clearance: The renal clearance of drug is 121 mL/min [1]
  Half-life: The concentration or amount of drug in body reduced by one-half in 12.6 hours [1]
  Metabolism: The drug is not metabolised [2]
  Vd: The volume of distribution (Vd) of drug is 124 L [3]

References

• [1] Pharmacokinetics of lisinopril. Am J Med. 1988 Sep 23;85(3B):25-30. doi: 10.1016/0002-9343(88)90346-4.
• [2] FDA Approved Drug Products: Lisinopril Oral Tablet
• [3] Goa KL, Balfour JA, Zuanetti G: Lisinopril. A review of its pharmacology and clinical efficacy in the early management of acute myocardial infarction. Drugs. 1996 Oct;52(4):564-88. doi: 10.2165/00003495-199652040-00011.